Research

Other Conditions

The following section lists some published research studies for various other conditions including autoimmune diseases (such as systemic lupus erythematous and rheumatoid arthritis), neurodegenerative/cognitive conditions (such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease), spinal cord injury, inflammatory bowel disease, lung disease (such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease), erectile dysfunction, diabetes (type I and type II) and many more.

We included studies that used various routes of administration and studies published beyond the past 5 years. We also included systematic reviews and meta-analyses for additional evidence. To view the abstracts or full texts use the provided links listed below the study title.

Rheumatoid Arthritis

• Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran. Ghoryani, M., Shariati-Sarabi, Z., Tavakkol-Afshari, J., Ghasemi, A., Poursamimi, J., & Mohammadi, M. (2019). Biomedicine and Pharmacotherapy, 109, 1834–1840. https://doi.org/10.1016/j.biopha.2018.11.056
• Intra-articular knee implantation of autologous bone marrow–derived mesenchymal stromal cells in rheumatoid arthritis patients with knee involvement: Results of a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial. Shadmanfar, S., Labibzadeh, N., Emadedin, M., Jaroughi, N., Azimian, V., Mardpour, S., … Aghdami, N. (2018). Cytotherapy. https://doi.org/10.1016/j.jcyt.2017.12.009
• Intravenous Infusion of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Rheumatoid Arthritis: A Phase Ia Clinical Trial. Park, E. H., Lim, H. suk, Lee, S., Roh, K., Seo, K. W., Kang, K. S., & Shin, K. (2018). Stem Cells Translational Medicine, 7(9), 636–642. https://doi.org/10.1002/sctm.18-0031
• Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Álvaro-Gracia JM, Jover JA, García-Vicuña R, et al.
  Annals of the Rheumatic Diseases 2017;76:196-202.
• Kafaja S, Segal K, Skerrett D, et al. Allogeneic mesenchymal precursor cells (MPCS): a novel approach to treating biologic refractory rheumatoid arthritis
  Annals of the Rheumatic Diseases 2017;76:566-567.
• Alvaro-Gracia J, Jover JΆ, García-Vicuña R, et al. The Use of Intravenous Expanded Allogeneic Adipose-Derived Mesenchymal Stem Cells in Refractory Rheumatoid Arthritis Patients. A Phase Ib/Iia Study.
  Annals of the Rheumatic Diseases 2014;73:504.
• Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: Safety and efficacy. Wang, L., Wang, L., Cong, X., Liu, G., Zhou, J., Bai, B., … Liu, Y. (2013). Stem Cells and Development, 22(24), 3192–3202. https://doi.org/10.1089/scd.2013.0023

Lupus

• A randomised double-blind, placebo-controlled trial of allogeneic umbilical cord-derived mesenchymal stem cell for lupus nephritis.Deng, D., Zhang, P., Guo, Y., & Lim, T. O. (2017). Annals of the Rheumatic Diseases, 76(8), 1436–1439. https://doi.org/10.1136/annrheumdis-2017-211073
• Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: A multicenter clinical study. Wang, D., Li, J., Zhang, Y., Zhang, M., Chen, J., Li, X., … Sun, L. (2014). Arthritis Research and Therapy, 16(2), R79. https://doi.org/10.1186/ar4520
• Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Gu, F., Wang, D., Zhang, H., Feng, X., Gilkeson, G. S., Shi, S., & Sun, L. (2014). Clinical Rheumatology, 33(11), 1611–1619. https://doi.org/10.1007/s10067-014-2754-4
• Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Wang, D., Zhang, H., Liang, J., Li, X., Feng, X., Wang, H., … Sun, L. (2013). Cell Transplantation, 22(12), 2267–2277. https://doi.org/10.3727/096368911X582769
• Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus . Sun, L., Wang, D., Liang, J., Zhang, H., Feng, X., Wang, H., … Shi, S. (2010). Arthritis and Rheumatism, 62(8), 2467–2475. https://doi.org/10.1002/art.27548
• Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: A pilot clinical study . Liang, J., Zhang, H., Hua, B., Wang, H., Lu, L., Shi, S., … Sun, L. (2010). Annals of the Rheumatic Diseases, 69(8), 1423–1429. https://doi.org/10.1136/ard.2009.123463
• Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Liang, J., Gu, F., Wang, H., Hua, B., Hou, Y., Shi, S., … Sun, L. (2010). Nature Reviews Rheumatology, 6(8), 486–489. https://doi.org/10.1038/nrrheum.2010.80
• Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Carrion, F., Nova, E., Ruiz, C., Diaz, F., Inostroza, C., Rojo, D., … Figueroa, F. (2010). Lupus, 19(3), 317–322. https://doi.org/10.1177/0961203309348983
• Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Carrion, F., Nova, E., Ruiz, C., Diaz, F., Inostroza, C., Rojo, D., … Figueroa, F. (2010). Lupus, 19(3), 317–322. https://doi.org/10.1177/0961203309348983

Amyolateral Sclerosis

• Oh, K.-W., Noh, M.-Y., Kwon, M.-S., Kim, H. Y., Oh, S.-I., Park, J., … Kim, S. H. (2018). Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis. Annals of Neurology, 84(3), 361–373. https://doi.org/10.1002/ana.25302
• Syková, E., Rychmach, P., Drahorádová, I., Konrádová, Ši., Růžičková, K., Voříšek, I., … Bojar, M. (2017). Transplantation of Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial. Cell Transplantation. https://doi.org/10.3727/096368916×693716
• Petrou, P., Gothelf, Y., Argov, Z., Gotkine, M., Levy, Y. S., Kassis, I., … Karussis, D. (2016). Safety and clinical effects of mesenchymal stem cells secreting neurotrophic factor transplantation in patients with amyotrophic lateral sclerosis. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2015.4321
• Staff, N. P., Madigan, N. N., Morris, J., Jentoft, M., Sorenson, E. J., Butler, G., … Windebank, A. J. (2016). Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS. Neurology. https://doi.org/10.1212/WNL.0000000000003359
• Glass, J. D., Hertzberg, V. S., Boulis, N. M., Riley, J., Federici, T., Polak, M., … Feldman, E. L. (2016). Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. Neurology. https://doi.org/10.1212/WNL.0000000000002889
• Oh, K.-W., Moon, C., Kim, H. Y., Oh, S., Park, J., Lee, J. H., … Kim, S. H. (2015). Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis. STEM CELLS Translational Medicine, 4(6), 590–597. https://doi.org/10.5966/sctm.2014-0212
• Rushkevich, Y. N., Kosmacheva, S. M., Zabrodets, G. V., Ignatenko, S. I., Goncharova, N. V., Severin, I. N., … Potapnev, M. P. (2015). The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-015-3017-3
• Mazzini, L., Gelati, M., Profico, D. C., Sgaravizzi, G., Projetti Pensi, M., Muzi, G., … Vescovi, A. L. (2015). Human neural stem cell transplantation in ALS: Initial results from a phase I trial. Journal of Translational Medicine, 13(1). https://doi.org/10.1186/s12967-014-0371-2
• Riley, J., Glass, J., Feldman, E. L., Polak, M., Bordeau, J., Federici, T., … Boulis, N. M. (2014). Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes. Neurosurgery, 74(1), 77–87. https://doi.org/10.1227/NEU.0000000000000156
• Feldman, E. L., Boulis, N. M., Hur, J., Johe, K., Rutkove, S. B., Federici, T., … Glass, J. D. (2014). Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes. Annals of Neurology. https://doi.org/10.1002/ana.24113
• Kwon, M.-S., Noh, M.-Y., Oh, K.-W., Cho, K.-A., Kang, B.-Y., Kim, K.-S., … Kim, S. H. (2014). The immunomodulatory effects of human mesenchymal stem cells on peripheral blood mononuclear cells in ALS patients. Journal of Neurochemistry, 131(2), 206–218. https://doi.org/10.1111/jnc.12814

**8 more ALS studies from 2006-2012**

Parkinson’s Disease

• Schiess, M., Suescun, J., Ellmore, T., Doursout, M.-F., Furr-Stimming, E., Miao, H., … Gee, A. (2019). Preliminary Report on the Safety and Tolerability of Bone marrow-derived Allogeneic Mesenchymal Stem Cells infused intravenously in Parkinson’s disease Patients (S16.008). Neurology, 92(15 Supplement).
• Kern, R., Garitaonandia, I., Gonzalez, R., Sherman, G., Semechkin, A., Braine, E., … Evans, A. (2019). Results of an Open Label, Dose Escalating, Phase 1 Clinical Trial Evaluating the Safety of a Human Neural Stem Cell Based Therapy in Parkinson’s Disease (P1.8-016). Neurology, 92(15 Supplement).
• Giordano, R., Canesi, M., Isalberti, M., Isaias, I. U., Montemurro, T., Viganò, M., … Pezzoli, G. (2014). Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: Translation into a phase I controlled, randomized clinical study. Journal of Translational Medicine. https://doi.org/10.1186/1479-5876-12-14
• Venkataramana, N. K., Pal, R., Rao, S. A. V, Naik, A. L., Jan, M., Nair, R., … Chaitanya, K. (2012). Bilateral transplantation of allogenic adult human bone marrow-derived mesenchymal stem cells into the subventricular zone of Parkinson’s disease: A pilot clinical study. Stem Cells International. https://doi.org/10.1155/2012/931902

Alzheimer’s Disease / Vascular Dementia

• He, Y., Jin, X., Wang, J., Meng, M., Hou, Z., Tian, W., … Fu, L. (2017). Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia. Cell and Tissue Banking, 18(1), 53–59. https://doi.org/10.1007/s10561-017-9609-6
• Kang, J. M., Yeon, B. K., Cho, S. J., & Suh, Y. H. (2016). Stem Cell Therapy for Alzheimer’s Disease: A Review of Recent Clinical Trials. Journal of Alzheimer’s Disease. https://doi.org/10.3233/JAD-160406
• Kim, H. J., Seo, S. W., Chang, J. W., Lee, J. Il, Kim, C. H., Chin, J., … Na, D. L. (2015). Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: A phase 1 clinical trial. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 1(2), 95–102. https://doi.org/10.1016/j.trci.2015.06.007

Spinal Cord Injury

• Vaquero, J., Zurita, M., Rico, M. A., Aguayo, C., Bonilla, C., Marin, E., … Ovejero, M. (2018). Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline. https://doi.org/10.1016/j.jcyt.2018.03.032
• Larocca, T. F., Macêdo, C. T., Souza, B. S. de F., Andrade-Souza, Y. M., Villarreal, C. F., Matos, A. C., … Dos Santos, R. R. (2017). Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, 19(10), 1189–1196. https://doi.org/10.1016/j.jcyt.2017.06.006
• J.W., H., T.-H., C., D.-H., P., J.-B., L., J.-Y., P., Y.-G., C., … Chung, Y.-G. (2016). Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. The Journal of Spinal Cord Medicine. https://doi.org/10.1179/2045772315Y.0000000048
• Zhu, H., Liu, Y., Feng, Y., Shen, C., Niu, F., Xu, Z., … Sun, D. (2016). Phase I–II clinical trial assessing safety and efficacy of umbilical cord blood mononuclear cell transplant therapy of chronic complete spinal cord injury. Cell Transplantation, 25(11), 1925–1943. https://doi.org/10.3727/096368916X691411
• Zhu, H., Liu, Y., Feng, Y., Shen, C., Niu, F., Xu, Z., … Sun, D. (2016). Phase I–II clinical trial assessing safety and efficacy of umbilical cord blood mononuclear cell transplant therapy of chronic complete spinal cord injury. Cell Transplantation, 25(11), 1925–1943. https://doi.org/10.3727/096368916X691411
• Chotivichit, A., Ruangchainikom, M., Chiewvit, P., Wongkajornsilp, A., & Sujirattanawimol, K. (2015). Chronic spinal cord injury treated with transplanted autologous bone marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: A case report. Journal of Medical Case Reports. https://doi.org/10.1186/s13256-015-0535-6
• Mendonça, M. V. P., Larocca, T. F., Souza, B. S. D. F., Villarreal, C. F., Silva, L. F. M., Matos, A. C., … Dos Santos, R. R. (2014). Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. Stem Cell Research and Therapy. https://doi.org/10.1186/scrt516
• Cheng, H., Liu, X., Hua, R., Dai, G., Wang, X., Gao, J., & An, Y. (2014). Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. Journal of Translational Medicine. https://doi.org/10.1186/s12967-014-0253-7
• Liu, J., Han, D., Wang, Z., Xue, M., Zhu, L., Yan, H., … Wang, H. (2013). Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells. Cytotherapy, 15(2), 185–191. https://doi.org/10.1016/j.jcyt.2012.09.005
• Cao, F. J., & Feng, S. Q. (2009). Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury. Chinese Medical Journal, Vol. 122, pp. 225–231. https://doi.org/10.3760/cma.j.issn.0366-6999.2009.02.021

Inflammatory Bowel Disease

• Shi, X., Chen, Q., & Wang, F. (2019). Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies. Stem Cell Research & Therapy, 10(1), 266. https://doi.org/10.1186/s13287-019-1336-4
• Barnhoorn, M. C., Wasser, M. N. J. M., Roelofs, H., Maljaars, P. W. J., Molendijk, I., Bonsing, B. A., … van der Meulen-de Jong, A. E. (2019). Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn’s Disease Perianal Fistulas. Journal of Crohn’s and Colitis. https://doi.org/10.1093/ecco-jcc/jjz116
• Cheng, F., Huang, Z., & Li, Z. (2019). Mesenchymal stem-cell therapy for perianal fistulas in Crohn’s disease: a systematic review and meta-analysis. Techniques in Coloproctology. https://doi.org/10.1007/s10151-019-02024-8
• Serrero, M., Grimaud, F., Philandrianos, C., Visée, C., Sabatier, F., & Grimaud, J. C. (2019). Long-term Safety and Efficacy of Local Microinjection Combining Autologous Microfat and Adipose-Derived Stromal Vascular Fraction for the Treatment of Refractory Perianal Fistula in Crohn’s Disease. Gastroenterology, 156(8), 2335-2337.e2. https://doi.org/10.1053/j.gastro.2019.01.032
• Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., … Lundby, L. (2019). Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn’s Disease. Gastroenterology, 156(8), 2208-2216.e1. https://doi.org/10.1053/j.gastro.2019.02.005
• Zhang, J., Lv, S., Liu, X., Song, B., & Shi, L. (2018). Umbilical cord mesenchymal stem cell treatment for Crohn’s disease: A randomized controlled clinical trial. Gut and Liver, 12(1), 73–78. https://doi.org/10.5009/gnl17035
• Turse, E. P., Dailey, F. E., Naseer, M., Partyka, E. K., Bragg, J. D., & Tahan, V. (2018). Stem cells for luminal, fistulizing, and perianal inflammatory bowel disease: A comprehensive updated review of the literature. Stem Cells and Cloning: Advances and Applications, Vol. 11, pp. 95–113. https://doi.org/10.2147/SCCAA.S135414
• Knyazev, O. V, Kagramanova, A. V, Fadeeva, N. A., Lishchinskaya, A. A., Boldyreva, O. N., Noskova, K. K., … Parfenov, A. I. (2018). Mesenchymal stromal cells of bone marrow and azathioprine in Crohn’s disease therapy. Terapevticheskii Arkhiv, 90(2), 47–52. https://doi.org/10.26442/terarkh201890247-52
• Panés, J., García-Olmo, D., Van Assche, G., Colombel, J. F., Reinisch, W., Baumgart, D. C., … Guadalajara, H. (2018). Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn’s Disease. Gastroenterology, 154(5), 1334-1342.e4. https://doi.org/10.1053/j.gastro.2017.12.020
• Philandrianos, C., Serrero, M., Grimaud, F., Magalon, J., Visée, C., Velier, M., … Sabatier, F. (2018). First clinical case report of local microinjection of autologous fat and adipose-derived stromal vascular fraction for perianal fistula in Crohn’s disease. Stem Cell Research & Therapy, 9(1), 4. https://doi.org/10.1186/s13287-017-0736-6
• Gregoire, C., Briquet, A., Pirenne, C., Lechanteur, C., Louis, E., & Beguin, Y. (2018). Allogeneic mesenchymal stromal cells for refractory luminal Crohn’s disease: A phase I–II study. Digestive and Liver Disease, Vol. 50, pp. 1251–1255. https://doi.org/10.1016/j.dld.2018.08.015
• Gregoire, C., Briquet, A., Pirenne, C., Lechanteur, C., Louis, E., & Beguin, Y. (2018). Allogeneic mesenchymal stromal cells for refractory luminal Crohn’s disease: A phase I–II study. Digestive and Liver Disease, Vol. 50, pp. 1251–1255. https://doi.org/10.1016/j.dld.2018.08.015

** more than 25 additional studies; 2010-2017**

Lung Disease

• Averyanov, A., Koroleva, I., Konoplyannikov, M., Revkova, V., Lesnyak, V., Kalsin, V., … Baklaushev, V. (2019). First‐in‐human high‐cumulative‐dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline. STEM CELLS Translational Medicine, sctm.19-0037. https://doi.org/10.1002/sctm.19-0037
• Fishman, J. E., Kim, G. J., Kyeong, N., Goldin, J. G., & Glassberg, M. K. (2019). Intravenous stem cell dose and changes in quantitative lung fibrosis and DLCO in the AETHER trial : a pilot study. 1, 7568–7572.
• Ntolios, P., Manoloudi, E., Tzouvelekis, A., Bouros, E., Steiropoulos, P., Anevlavis, S., … Froudarakis, M. E. (2018). Longitudinal outcomes of patients enrolled in a phase Ib clinical trial of the adipose-derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis. Clinical Respiratory Journal, 12(6), 2084–2089. https://doi.org/10.1111/crj.12777
• Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y., & Liu, Y. (2017). Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report. Experimental and Therapeutic Medicine, 13(5), 1922–1926. https://doi.org/10.3892/etm.2017.4222
• Limper, A. H. (2017). Safety of IV Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis. Chest, 151(5), 951–952. https://doi.org/10.1016/j.chest.2016.12.015
• Glassberg, M. K., Minkiewicz, J., Toonkel, R. L., Simonet, E. S., Rubio, G. A., DiFede, D., … Hare, J. M. (2017). Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial. Chest, 151(5), 971–981. https://doi.org/10.1016/j.chest.2016.10.061
• Stolk, J., Broekman, W., Mauad, T., Zwaginga, J. J., Roelofs, H., Fibbe, W. E., … Hiemstra, P. S. (2016). A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. QJM. https://doi.org/10.1093/qjmed/hcw001
• Chambers, D. C., Enever, D., Ilic, N., Sparks, L., Whitelaw, K., Ayres, J., … Hopkins, P. M. A. (2014). A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. Respirology, 19(7), 1013–1018. https://doi.org/10.1111/resp.12343
• Chambers, D. C., Enever, D., Ilic, N., Sparks, L., Whitelaw, K., Ayres, J., … Hopkins, P. M. A. (2014). A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. Respirology, 19(7), 1013–1018. https://doi.org/10.1111/resp.12343
• Weiss, D. J., Casaburi, R., Flannery, R., LeRoux-Williams, M., & Tashkin, D. P. (2013). A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest. https://doi.org/10.1378/chest.12-2094
• Tzouvelekis, A., Paspaliaris, V., Koliakos, G., Ntolios, P., Bouros, E., Oikonomou, A., … Bouros, D. (2013). A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis. Journal of Translational Medicine, 11(1). https://doi.org/10.1186/1479-5876-11-171
• Ribeiro-Paes, J. T., Bilaqui, A., Greco, O. T., Ruiz, M. A., Marcelino, M. Y., Stessuk, T., … Lago, M. R. (2011). Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema. International Journal of Chronic Obstructive Pulmonary Disease, 6, 63–71. https://doi.org/10.2147/COPD.S15292

Male Sexual Dysfunction

• Haney, N. M., Gabrielson, A., Kohn, T. P., & Hellstrom, W. J. G. (2019). The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies. Sexual Medicine Reviews, 7(2), 313–320. https://doi.org/10.1016/j.sxmr.2018.04.001
• Zhang, C., Luo, D., Li, T., Yang, Q., Xie, Y., Chen, H., … Liu, G. (2019). Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in Diabetic Erectile Dysfunction Rats. Stem Cells International, 2019, 1–13. https://doi.org/10.1155/2019/2168709
• Chung, E. (2019). Stem cell therapy in diabetic men with erectile dysfunction: a step closer to safe and effective regenerative technology. Annals of Translational Medicine, 7(Suppl 1), S40. https://doi.org/10.21037/atm.2019.02.28
• Lokeshwar, S. D., Patel, P., Shah, S. M., & Ramasamy, R. (2019). A Systematic Review of Human Trials Using Stem Cell Therapy for Erectile Dysfunction. Sexual Medicine Reviews. https://doi.org/10.1016/j.sxmr.2019.08.003
• Haahr, M. K., Harken Jensen, C., Toyserkani, N. M., Andersen, D. C., Damkier, P., Sørensen, J. A., … Lund, L. (2018). A 12-Month Follow-up After a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. Urology. https://doi.org/10.1016/j.urology.2018.06.018
• Al Demour, S., Jafar, H., Adwan, S., Alsharif, A., Alhawari, H., Alrabadi, A., … Awidi, A. (2018). Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase i Clinical Trial. Urologia Internationalis, 101(3), 358–365. https://doi.org/10.1159/000492120
• Protogerou, V., Michalopoulos, E., Mallis, P., Gontika, I., Liakouras, C., Giokas, C. S.-, … Deliveliotis, C. (2018). Stem cell therapy for erectile dysfunction: Preliminary results from a single-center pilot study in Greece. Hellenic Urology, 29(3). https://doi.org/10.19264/hj.v29i3.195
• Lander, E. B., & Berman, M. H. (2018). Autologous Stromal Vascular Fraction Containing Stem Cells Combined with Low Intensity Shock Wave for the Treatment of Human Erectile Dysfunction. Journal of Stem Cell Research & Therapy, 08(09). https://doi.org/10.4172/2157-7633.1000438
• Haahr, M. K., Lund, L., Jensen, C. H., Andersen, D. C., Damkier, P., Sheikh, S. P., … Sørensen, J. A. (2016). Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. https://doi.org/10.1016/j.ebiom.2016.01.024
• Yiou, R., Hamidou, L., Birebent, B., Bitari, D., Lecorvoisier, P., Contremoulins, I., … Rouard, H. (2016). Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. European Urology, 69(6), 988–991. https://doi.org/10.1016/j.eururo.2015.09.026
• Levy, J. A., Marchand, M., Iorio, L., Zribi, G., & Zahalsky, M. P. (2015). Effects of Stem Cell Treatment in Human Patients With Peyronie Disease. The Journal of the American Osteopathic Association, 115(10), e8-13. https://doi.org/10.7556/jaoa.2015.124
• Bahk, J. Y., Jung, J. H., Han, H., Min, S. K., & Lee, Y. S. (2010). Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: Preliminary report of 7 cases. In Experimental and Clinical Transplantation (Vol. 8).

Diabetes

• Sheykhhasan, M. (2019). Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review. Current Stem Cell Research & Therapy, 14(1), 75–76. https://doi.org/10.2174/1574888×1401181217125608
• Stiner, R., Alexander, M., Liu, G., Liao, W., Liu, Y., Yu, J., … Lakey, J. R. T. (2019). Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell and Tissue Research. https://doi.org/10.1007/s00441-019-03046-2
• Aziz, J., Liao, G., Adams, Z., Rizk, M., Shorr, R., & Allan, D. S. (2019). Systematic review of controlled clinical studies using umbilical cord blood for regenerative therapy: Identifying barriers to assessing efficacy. Cytotherapy. https://doi.org/10.1016/j.jcyt.2019.08.004
• Estrada, E. J., Decima, J. L., Bortman, G., Roberti, J., Romero, E. B., Samaja, G., … Gutiérrez, S. (2019). Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial. Cell Transplantation, 096368971988381. https://doi.org/10.1177/0963689719883813
• Cho, J., D’Antuono, M., Glicksman, M., Wang, J., & Jonklaas, J. (2018). A review of clinical trials: mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. American Journal of Stem Cells, 7(4), 82–93. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30510843
• Bhansali, S., Dutta, P., Kumar, V., Yadav, M. K., Jain, A., Mudaliar, S., … Bhansali, A. (2017). Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled Comparative Study. Stem Cells and Development, 26(7), 471–481. https://doi.org/10.1089/scd.2016.0275
• Cai, J., Wu, Z., Xu, X., Liao, L., Chen, J., Huang, L., … Tan, J. (2016). Umbilical Cord Mesenchymal Stromal Cell with Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. Diabetes Care, 39(1), 149–157. https://doi.org/10.2337/dc15-0171
• Hu, J., Wang, Y., Gong, H., Yu, C., Guo, C., Wang, F., … Xu, H. (2016). Long term effect and safety of wharton’s jelly-derived mesenchymal stem cells on type 2 diabetes. Experimental and Therapeutic Medicine, 12(3), 1857–1866. https://doi.org/10.3892/etm.2016.3544
• El-Badawy, A., & El-Badri, N. (2016). Clinical efficacy of stem cell therapy for diabetes mellitus: A meta-analysis. PLoS ONE, 11(4). https://doi.org/10.1371/journal.pone.0151938
• Packham, D. K., Fraser, I. R., Kerr, P. G., & Segal, K. R. (2016). Allogeneic Mesenchymal Precursor Cells (MPC) in Diabetic Nephropathy: A Randomized, Placebo-controlled, Dose Escalation Study. EBioMedicine, 12, 263–269. https://doi.org/10.1016/j.ebiom.2016.09.011
• Qin, H. L., Zhu, X. H., Zhang, B., Zhou, L., & Wang, W. Y. (2016). Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot*. Experimental and Clinical Endocrinology and Diabetes, 124(8), 497–503. https://doi.org/10.1055/s-0042-103684
• Bhansali, A., Asokumar, P., Walia, R., Bhansali, S., Gupta, V., Jain, A., … Khandelwal, N. (2014). Efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study. Cell Transplantation, 23(9), 1075–1085. https://doi.org/10.3727/096368913X665576
• Hu, J., Yu, X., Wang, Z., Wang, F., Wang, L., Gao, H., … Wang, Y. (2013). Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocrine Journal, 60(3), 347–357. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23154532