Conditions

Multiple Sclerosis

Multiple sclerosis (MS) is the most common autoimmune disease affecting the central nervous system. In MS, the immune system attacks the myelin sheath, a protective material around nerves in a process called demyelination. Damage to the myelin sheath disrupts the transmission of information within the brain and between the brain and the body resulting in various neurological symptoms.

The most common symptoms of MS include fatigue, weakness, numbness and tingling, blurred vision, double vision, poor coordination and balance, and others. Tremor, paralysis and blindness are less common symptoms of MS.

It is estimated that more than 2 million people have MS worldwide. Although anyone can develop MS, it is 2-3 times more common in women and overall more common in Caucasians of northern European ancestry.

MS is characterized by demyelination, progressive neurological dysfunction, and episodes of remission and relapse. However, MS is an unpredictable disease with different clinical presentations and as such four subtypes of MS have been defined. They include clinically isolated syndrome, relapsing-remitting MS, secondary progressive MS and primary progressive MS.

There is currently no cure and no proven therapies to stop or reverse the progressive phases of the disease. The conventional approach includes medications, physical therapy, exercise therapy and others. Although numerous FDA approved drugs exist for MS, their impact is limited and appear to be effective at reducing the inflammatory aspect of the disease and reducing rate of relapse but do not appear to limit degeneration of the central nervous system. Evidence exists to support a reparative role of stem cell therapy to suppress inflammation and rebuild the injured nervous system in demyelinating diseases such as MS.

Numerous research studies have demonstrated that intravenous stem cell therapy is safe and effective in the treatment of MS. Stem cell therapy has been shown to improve various symptoms associated with MS, reduce rate of relapse and improve quality of life.

Based on early human clinical trials there appears to be a strong argument for the safe and effective use of intravenous stem cell therapy in the treatment of MS. While we wait for phase II/III trials the current data is encouraging and supports use of stem cell therapy in the clinical setting.

Proven benefits from early clinical studies of stem cell therapy in multiple sclerosis:

• Improvement in bladder, bowel, and sexual dysfunction (Riordan et al)
• Improvement in walking (Riordan et al, Cohen et al)
• Improvement in upper extremity physical function, energy and fatigue (Riordan et al)
• Improvement in neurological status measured by Expanded Disability Scale Score (EDSS) (Riordan et al, Meng et al, Cohen et al, Li et al)
• Improvement in quality of life (Riordan et al)
• Reduction in number of brain lesions (Meng et al, Llufriu et al)
• Reduction in average number of relapses (Meng et al, Li et al)

Specific Conclusions From Selected Studies:

“We have shown that the intravenous infusion of UCMSC over several days is safe in subjects with MS. Additionally, UCMSC infusions may hold benefits, since this small study group saw improvement in bladder, bowel, and sexual dysfunction, walking, upper extremity physical function, energy and fatigue, general perspective of a positive health change and improved quality of life, and MRI lesions.”

• Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. (Riordan et al, 2018)

“Our findings confirm that UCMSCs have function of immune regulation and nerve protection, indicating the feasibility of UCMSC transplantation for multiple sclerosis.”

• Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis. (Meng et al, 2018)

“The present study demonstrates that infusion of AdMSCs is a safe and feasible procedure in patients with SPMS. Although the study was not powered to determine the efficacy, some hint of efficacy was observed by the use of MRI and evoked potentials.”

• Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study. (Fernandez et al, 2018)

“Our phase I study results support the feasibility, safety, and tolerability of IV administration of autologous, culture-expanded, bone-marrow-derived MSCs in MS.”

• Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis. (Cohen et al, 2018)

“During a 1-year observation, no significant adverse effects were found, indicating the clinical safety could be well accepted. The significantly lower relapse occurrence and EDSS scores were found in the experimental group compared to the control group.” “Our study contributed, in part, to providing more evidence for the potential of hUC-MSCs as a therapy for MS.”

• The Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells as a Novel Cellular Therapy for Multiple Sclerosis. (Li et al, 2014)

“Bone-marrow-MSCs are safe and may reduce inflammatory MRI parameters supporting their immunomodulatory properties.”

• Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis. (Llufriu et al, 2014)

For additional information on stem cell therapy in MS and more details regarding these studies please visit our Research Archive.

Sources:

• https://www.nationalmssociety.org/nationalmssociety/media/msnationalfiles/brochures/brochure-just-the-facts.pdf
• https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s#question-How-many-people-have-MS
• Rice, C. M., Marks, D. I., Walsh, P., Kane, N. M., Guttridge, M. G., Redondo, J., … Scolding,N. J. (2015). Repeat infusion of autologous bone marrow cells in multiple sclerosis: protocol for a phase I extension study (SIAMMS-II). BMJ Open, 5(9), e009090. https://doi.org/10.1136/bmjopen-2015-009090
• Hou, Z. L., Liu, Y., Mao, X. H., Wei, C. Y., Meng, M. Y., Liu, Y. H., … Xiao, Z. C. (2013). Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis. Cell Adhesion and Migration, 7(5), 404–407. https://doi.org/10.4161/cam.26941